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  • Title: Co-repressor complexes and remodelling chromatin for repression.
    Author: Wolffe AP, Urnov FD, Guschin D.
    Journal: Biochem Soc Trans; 2000; 28(4):379-86. PubMed ID: 10961924.
    Abstract:
    Recent progress identifies targeted chromatin remodelling by co-repressor complexes as being an integral component of transcriptional silencing. Here we discuss how chromatin structure and the basal transcriptional machinery are manipulated by the co-repressor complex containing the Mi-2 nucleosomal ATPase, the histone-binding protein RbAp48 and histone deacetylase and by the co-repressor complex containing SIN3, RbAp48 and histone deacetylase. Remarkably, both of these complexes also contain methyl-CpG-binding proteins. This observation provides a molecular mechanism to integrate DNA methylation fully into gene control in vertebrates.
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