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  • Title: CD1-restricted T-cell responses and microbial infection.
    Author: Park SH, Bendelac A.
    Journal: Nature; 2000 Aug 17; 406(6797):788-92. PubMed ID: 10963609.
    Abstract:
    CD1, a conserved family of major histocompatibility (MHC)-like glycoproteins in mammals, specializes in capturing lipid rather than peptide antigen for presentation to T lymphocytes. The principles and mechanisms of this newly discovered immune strategy differ markedly from those governing classical MHC-peptide presentation. They might be exploited for the design of new lipid-based microbial vaccines and adjuvants.
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