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  • Title: An NMR spectroscopic identity test for the control of the capsular polysaccharide from Haemophilus influenzae type b.
    Author: Lemercinier X, Jones C.
    Journal: Biologicals; 2000 Sep; 28(3):175-83. PubMed ID: 10964444.
    Abstract:
    We describe the use of Nuclear Magnetic Resonance (NMR) spectroscopy to control the identity of purified bulk capsular polysaccharide [called poly(ribosylribitolphosphate) or PRP] from Haemophilus influenzae type b (Hib), and derivatised forms, used in the production of Hib polysaccharide-protein conjugate vaccines. We describe the approaches we have developed to validate this test.
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