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  • Title: [Immunology in the medical practice.XXXII. Transplantation of autologous hematopoietic stem cells for treatment of refractory auto-immune diseases; preliminary favorable results with 35 patients].
    Author: Vlieger AM, van den Hoogen FH, Brinkman DM, van Laar JM, Schipperus M, Kruize AA, Wulffraat NM.
    Journal: Ned Tijdschr Geneeskd; 2000 Aug 12; 144(33):1588-92. PubMed ID: 10965368.
    Abstract:
    The objective of this study was to document the experiences in the first Dutch pilot studies of the effect of transplantation of autologous haematopoietic stem cells in patients with therapy-resistant autoimmune disease. The first results in 21 adults and 14 children are promising: remission of the disease was achieved in 13 patients, while in the others a significant reduction of disease activity was seen with a corresponding improvement of the quality of life. Infectious complications were frequently observed. Two children with systemic juvenile idiopathic arthritis developed a fatal infection-associated macrophage activation syndrome. Multicentre randomised studies are necessary to study the effects of autologous stem cell transplantation and modifications such as T-cell depletion.
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