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  • Title: [Decreased activity of 11-beta-hydroxysteroid dehydrogenase in patients with Cushing's syndrome].
    Author: Stiefel P, Jiménez L, García-Morillo JS, Leal A, Villar J, Carneado J.
    Journal: Med Clin (Barc); 2000 Jun 17; 115(3):90-2. PubMed ID: 10965482.
    Abstract:
    BACKGROUND: To study 11 beta-hydroxysteroid dehydrogenase activity in Cushing's syndrome. PATIENTS AND METHOD: Measurements of free cortisol, cortisone, tetrahydrocortisol and tetrahydrocortisone in 24 h urine samples of patients with Cushing's syndrome and controls. RESULTS: The cortisol to cortisone and tetrahydrocortisol to tetrahydrocortisone relationship was significant (in controls, r = 0.70; p < 0.0001, and r = 0.75; p < 0.0001) respectively, but it was not in patients with Cushing's syndrome. CONCLUSIONS: 11 beta-hydroxysteroid dehydrogenase activity is decreased in patients with Cushing's syndrome.
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