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  • Title: Prevention of blood-transfusion-induced impairment of anastomotic healing by leucocyte depletion in rats.
    Author: Apostolidis SA, Michalopoulos AA, Hytiroglou PM, Papadopoulos BN, Fachantidis EP, Basdanis GA, Catsohis CD.
    Journal: Eur J Surg; 2000 Jul; 166(7):562-7. PubMed ID: 10965836.
    Abstract:
    OBJECTIVE: To find out what effect whole blood and leucocyte-depleted blood transfusions had on the healing process of intestinal anastomoses in rats. DESIGN: Experimental study. SETTING: Teaching hospital, Greece. SUBJECTS: 100 Wistar rats in five groups of 20 each. INTERVENTIONS: Small and large bowel anastomoses were made and the five groups were given normal saline, homologous whole blood, heterologous whole blood obtained from PVG rats, homologous leucocyte-depleted blood or heterologous leucocytedepleted blood during the operation. MAIN OUTCOME MEASURES: Bursting pressures of anastomoses on the third and seventh postoperative days and infective complications. RESULTS: The groups given whole blood transfusions had significantly more anastomotic abscesses than controls (p = 0.003 compared with heterologous, p = 0.05 compared with homologous for the small bowel, and p = 0.007 for the large bowel). The pressure measurements indicated a significant reduction in anastomotic strength in the same groups compared with the control group (p = 0.0001/p = 0.001 on the third postoperative day, and p = 0.00001/p = 0.0004 on the seventh postoperative day for small and large bowel, respectively). There was no reduction in anastomotic strength in the leucocyte-depleted blood groups. CONCLUSIONS: Transfusion of leucocyte-depleted blood does not seem to impair intestinal anastomotic healing and carries an acceptable incidence of postoperative complications.
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