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  • Title: Intracellular accumulation of polyphosphate by the yeast Candida humicola G-1 in response to acid pH.
    Author: McGrath JW, Quinn JP.
    Journal: Appl Environ Microbiol; 2000 Sep; 66(9):4068-73. PubMed ID: 10966430.
    Abstract:
    Cells of a newly isolated environmental strain of Candida humicola accumulated 10-fold more polyphosphate (polyP), during active growth, when grown in complete glucose-mineral salts medium at pH 5.5 than when grown at pH 7.5. Neither phosphate starvation, nutrient limitation, nor anaerobiosis was required to induce polyP formation. An increase in intracellular polyP was accompanied by a 4.5-fold increase in phosphate uptake from the medium and sixfold-higher levels of cellular polyphosphate kinase activity. This novel accumulation of polyP by C. humicola G-1 in response to acid pH provides further evidence as to the importance of polyP in the physiological adaptation of microbial cells during growth and development and in their response to environmental stresses.
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