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  • Title: Structural evidence for evolution of the beta/alpha barrel scaffold by gene duplication and fusion.
    Author: Lang D, Thoma R, Henn-Sax M, Sterner R, Wilmanns M.
    Journal: Science; 2000 Sep 01; 289(5484):1546-50. PubMed ID: 10968789.
    Abstract:
    The atomic structures of two proteins in the histidine biosynthesis pathway consist of beta/alpha barrels with a twofold repeat pattern. It is likely that these proteins evolved by twofold gene duplication and gene fusion from a common half-barrel ancestor. These ancestral domains are not visible as independent domains in the extant proteins but can be inferred from a combination of sequence and structural analysis. The detection of subdomain structures may be useful in efforts to search genome sequences for functionally and structurally related proteins.
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