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  • Title: tRNAs undermethylation in a met-regulatory mutant of Saccharomyces cerevisiae.
    Author: Fesneau C, de Robichon-Szulmajster H, Fradin A, Feldmann H.
    Journal: Biochimie; 1975; 57(1):49-59. PubMed ID: 1096967.
    Abstract:
    A study of in vivo and in vitro methylation of tRNAs in regulatory mutants affected in methionine-mediated repression (eth2, eth3, eth10) has led to the following results: 1) The eth2-2 carrying strain presents a great undermethylation of its tRNAs of the same order of magnitude as observed during methionine starvation of methionine auxotrophs. 2) This undermethylation leads to a shift of the tRNAIII met peak on a BD cellulose column, while tRNAIII met peak is unchanged. 3) The study of a double mutant strain carrying eth2 and met2 mutations has shown that this undermethylation is a consequence of the high internal pool of methionine. 4) Undermethylation unequally affects the different bases and the different tRNA species.
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