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  • Title: Selective IgA deficiency---some perspectives.
    Author: Horowitz S, Hong R.
    Journal: Birth Defects Orig Artic Ser; 1975; 11(1):129-33. PubMed ID: 1096975.
    Abstract:
    The clinical spectrum of IgA deficiency varies from good health to respiratory, gastrointestinal, autoimmune and malignant disorders. Evaluation of B lymphocytes with surface IgA receptors in this disease reveals cap formation, decreased to normal density of IgA receptors, and IgA secretion following pokeweed stimulation. Further study of antigen-induced B-lymphocyte phenomena is needed. The presence of decreased numbers of T-cell markers in some individuals with IgA deficiency suggests a T-"helper" cell defect.
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