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  • Title: T Cells in immunodeficiencies as evaluated by an antihuman T-cell serum.
    Author: Touraine JL, Kiszkiss DF, Choi YS, Good RA.
    Journal: Birth Defects Orig Artic Ser; 1975; 11(1):22-7. PubMed ID: 1096979.
    Abstract:
    An antihuman T-cell has been prepared in rabbits by infecting lymphocytes from a patient with Bruton-type agammaglobulinemia and absorption with cultured B-lymphoblast cells. Cytotoxicity of the antiserum was assayed with peripheral blood lymphocytes in the presence of rabbit complement and its specificity for T vs B cells was verified. This anti-T-cell serum killed 66% (range 49-78) of normal blood lymphocytes. In patients with Bruton-type agammaglobulinemia the percentage of cells sensitive to the antiserum was above normal (77-89%), whereas it was decreased in some patients with lepromatous leprosy or under antilymphocyte globulin therapy.
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