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  • Title: Effects on ribosomes of the substitution of spermidine or divalent cations for magnesium ions.
    Author: Igarashi K, Sugawara K, Hirose S.
    Journal: J Biochem; 1975 Apr; 77(4):753-9. PubMed ID: 1097433.
    Abstract:
    The inactivation of rat liver ribosomes (polysomes) resulting from the replacement of bound magnesium by spermidine has been studied using a dialysis method. Inactivation of the ribosomes (polysomes) occurred when more than 40% of the Mg2+ originally bound to ribosomes in the presence of 2 mM Mg2+ was replaced by spermidine. The polypeptide-synthesizing activity of polysomes was retained partially when Mg2+ was replaced by Mn2+ by dialysis. E. coli 30S ribosomal subunits were more resistant to inactivation due to the replacement of Mg2+ by spermidine than the 50S subunits.
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