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  • Title: [Midodrine (Gutron) treatment of permanent arterial hypotension in a chronic hemodialysis patient].
    Author: Montagnac R, Clavel P, Delhotal-Landes B, Flouvat B, Poulain S, Schillinger F.
    Journal: Nephrologie; 2000; 21(4):179-83. PubMed ID: 10976433.
    Abstract:
    Chronic hypotension, although unfrequent in uremic patients on hemodialysis, accentuates the deterioration of patients physical state and thus, their general well-being. These patients often experience acute intradialytic symptoms and respond very poorly to conventional therapies. Well tolerated, midodrine is a suitable and effective choice as it raises blood pressure significantly through its effect on peripheral alpha-adrenergic receptors. The authors report observing the use of midodrine by a dialysis patient during the longest time period published to date, documented by a pharmacokinetic study, and that confirms the excellent results and proves long term tolerance for that drug.
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