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  • Title: Stress or drug priming induces reinstatement of extinguished conditioned place preference.
    Author: Wang B, Luo F, Zhang WT, Han JS.
    Journal: Neuroreport; 2000 Aug 21; 11(12):2781-4. PubMed ID: 10976962.
    Abstract:
    To construct a model for the relapse of drug use, we investigated the reinstatement of morphine-induced conditioned place preference (CPP) in rats. After the morphine CPP paradigm was established, rats were left extinguishing for 9 days, then exposed to 15 min of random foot shock or s.c. drug priming with different doses of morphine or amphetamine, respectively. Foot shock or a higher dose (0.25 mg/kg) of both drugs could reinstate the CPP induced by 4 mg/kg of morphine after a 9-day extinction, while a lower dose (0.125 mg/kg) of both drugs had no effect. It is concluded that the CPP extinction-reinstatement paradigm might be used as a model to investigate the mechanism of relapse in addicts.
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