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  • Title: A controlled study of a tetracyclic antidepressant--maprotiline (Ludiomil).
    Author: Kessell A, Holt NF.
    Journal: Med J Aust; 1975 Jun 21; 1(25):773-6. PubMed ID: 1097869.
    Abstract:
    Maprotiline (Ludiomil) is a dibenzo bicyclooctadiene pharmacologically related to the tricyclic antidepressants and stereochemically having a tetracyclic structure. A controlled, double-blind comparison of maprotiline and imipramine in a group of 71 female outpatients with primary depression is presented. Maprotiline was found to be at least as effective as imipramine and significantly better in depressive neurosis. It also showed a bipolar action, being effective in both agitation and retardation.
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