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  • Title: Purification and characterization of two hemolysins from Stichodactyla helianthus.
    Author: Lanio ME, Morera V, Alvarez C, Tejuca M, Gómez T, Pazos F, Besada V, Martínez D, Huerta V, Padrón G, de los Angeles Chávez M.
    Journal: Toxicon; 2001; 39(2-3):187-94. PubMed ID: 10978735.
    Abstract:
    Two hemolysins, Sticholysin I (St I) and Sticholysin II (St II) were purified from the sea anemone Stichodactyla helianthus combining gel filtration and ion exchange chromatography. The amino acid composition of both cytolysins was determined revealing a high proportion of glycine, lysine, tyrosine and non-polar amino acids (alanine, leucine and valine). Cysteine was not found in either polypeptide. Molecular masses of St I and St II were 19401 and 19290 Da, respectively. N-terminal sequence analysis of St I and St II showed a high homology between them suggesting they are isoforms of the same cytolysin. Compared with other sea anemone cytolysins, St I and St II contain a 22 amino acid insertion fragment also present in Eq T II/Tn C and probably in CaT I and Hm T and absent in C III, the major hemolysin previously reported in this anemone.
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