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  • Title: Effect of anti-TRH-receptor antibody on corticosterone release from rat adrenal gland in vitro.
    Author: Mitsuma T, Kayama M, Rhue N, Hirooka Y, Mori Y, Adachi K, Ping J, Nogimori T.
    Journal: Endocr Regul; 1996 Sep; 30(3):129-131. PubMed ID: 10979043.
    Abstract:
    The effect of anti-thyrotropin-releasing hormone (TRH) receptor antibody on corticosterone release from the rat adrenal gland in vitro was studied. The adrenal glands were incubated in medium 199 with 1.0 mg/ml bacitracin (pH 7.4, medium) for 20 min and the release of corticosterone into the medium was measured by radioimmunoassay. TRH inhibited corticosterone release from the adrenal gland in a dose-related manner. The inhibitory effect of TRH on corticosterone release from the adrenal gland was prevented by the addition of anti-TRH-receptor antibody. The present findings suggest that TRH inhibits corticosterone release from the adrenal gland in vitro and its effect is mediated via TRH receptor.
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