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  • Title: Trichlortriethylamine (TS-160 Spofa) in combination chemotherapy of malignant lymphomas.
    Author: Klener P, Donner L.
    Journal: Neoplasma; 1975; 22(1):55-62. PubMed ID: 1097949.
    Abstract:
    Thirteen patients with disseminated malignant lymphomas were treated with combination chemotherapy which included trichlortriethyl amine (TS-160), vincristine (Oncovin), procarbazine hydrochloride (Natulan) and prednisone. All patients but two received some form of chemotherapy and/or radiotherapy prior to being started on four-drug regimen. Good response to the combination chemotherapy was recorded in 84% of patients, while complete remission was achieved in 23% of cases. Drug toxicity has not proved to be a major problem in the combination used. Nausea and vomiting were the side effects the most frequently observed.
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