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  • Title: Eradication of non-typhoid salmonellae in acute enteritis after therapy with ofloxacin for 5 or 10 days.
    Author: Voltersvik P, Halstensen A, Langeland N, Digranes A, Peterson LE, Rolstad T, Solberg CO.
    Journal: J Antimicrob Chemother; 2000 Sep; 46(3):457-9. PubMed ID: 10980174.
    Abstract:
    Eradication of non-typhoid salmonellae was evaluated in a randomized, double-blinded study of 49 patients with acute enteritis after therapy with ofloxacin 400 mg once daily for 5 or 10 days. Early eradication of salmonellae was found in 57% of patients in the 5 day therapy group and in 74% of patients in the 10 day therapy group. This difference was larger among severely ill patients. Together with our previous study of ofloxacin therapy for 3 days or placebo, this shows that early eradication of non-typhoid salmonellae increases with duration of ofloxacin therapy without an increase in persistence of salmonellae in stools or development of resistant strains.
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