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  • Title: The role of chromium(V) in the mechanism of chromate-induced oxidative DNA damage and cancer.
    Author: Sugden KD, Stearns DM.
    Journal: J Environ Pathol Toxicol Oncol; 2000; 19(3):215-30. PubMed ID: 10983888.
    Abstract:
    The role that high valent chromium intermediates play in the oxidative DNA damage produced by the human carcinogen chromate Cr(VI) is of increasing interest for establishing a mechanism of genotoxicity and mutagenicity for this metal. In this review, the authors summarize experimental evidence for the formation of high valent chromium complexes (primarily the +5 oxidation state) and radical species from the reductive metabolism of Cr(VI). A case is made for a direct- or metal-mediated pathway by high valent chromium to initiate oxidative DNA damage, although the role of radical species in this oxidative process cannot be ruled out.
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