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  • Title: Interaction of human Ku70 with TRF2.
    Author: Song K, Jung D, Jung Y, Lee SG, Lee I.
    Journal: FEBS Lett; 2000 Sep 08; 481(1):81-5. PubMed ID: 10984620.
    Abstract:
    Ku, a heterodimer of 70- and 80-kDa subunits, plays a general role in the metabolism of DNA ends in eukaryotic cells, including double-strand DNA break repair, V(D)J recombination, and maintenance of telomeres. We have utilized the yeast two-hybrid system to identify Ku70-interacting proteins other than Ku80. Two reactive clones were found to encode the dimerization domain of TRF2, a mammalian telomeric protein that binds to duplex TTAGGG repeats at chromosome ends. This interaction was confirmed using bacterial fusion proteins and co-immunoprecipitations from eukaryotic cells overexpressing TRF2. The transfected TFR2 colocalized with Ku70.
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