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  • Title: Interaction of poly methyl vinyl ether/maleic anhydride-dimiristoyl phosphatidylcholine: a model bioadhesion study.
    Author: Nuñez JL, Ballesteros MP, Lastres JL, Castro RM.
    Journal: Biomaterials; 2000 Nov; 21(21):2131-5. PubMed ID: 10985485.
    Abstract:
    The objective of this work is to study the interaction of a copolymer, poly methyl vinyl ether/maleic anhydride (PMV/MA) used in pharmaceutical dosage form and a phospholipid L-alpha-dimiristoyl phosphatidylcholine (DMPC) with the aim of developing a bioadhesive system. Glycerine is the plastifiant used to make PMV/MA insoluble. We have studied copolymer-plastifiant compatibility with differential scanning calorimetry and we have studied the influence that the solvents produce on the copolymer by infrared spectroscopy. Monolayer experiments were carried out with a Wilhelmy-type surface balance. The purpose of these experiments is to obtain molecular information about interaction PMV/MA-glycerine system with DMPC. The results show that there are attractive forces and it is a spontaneous process.
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