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  • Title: Effect of low-dose heparin on incidence of postoperative thrombosis in orthopaedic patients.
    Author: Abraham-Inpijn L, Vreeken J.
    Journal: Arch Chir Neerl; 1975; 27(1):63-8. PubMed ID: 1098580.
    Abstract:
    In a double-blind study, using matched controls, thrombo-embolic prophylaxis with subcutaneous low-dose heparin was studied in 25 patients admitted for orthopaedic surgery. Deep vein thrombosis (DVT) was detected by clinical assessment and by the 125I-fibrinogen leg-scanning technique. As a control the T-1/2 of the 125I-fibrinogen was measured. Six of the 13 patients in the control group and one in the heparin-treated group developed deep vein thrombosis within the first eight postoperative days.
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