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  • Title: Role of angiogenesis in benign, premalignant and malignant vulvar lesions.
    Author: MacLean AB, Reid WM, Rolfe KJ, Gammell SJ, Pugh HE, Gatter KC, Wong Te Fong AC, Crow JC, Perrett CW.
    Journal: J Reprod Med; 2000 Aug; 45(8):609-12. PubMed ID: 10986676.
    Abstract:
    OBJECTIVE: To investigate the presence of angiogenic factors in benign, premalignant and malignant vulvar lesions. STUDY DESIGN: Immunohistochemical demonstration of vascular endothelial growth factor (VEGF) and platelet-derived endothelial cell growth factor (PD-ECGF) in normal vulvar skin, lichen sclerosus, vulvar intraepithelial neoplasia (VIN) and vulvar cancer. RESULTS: VEGF was found in the majority of vulvar cancers but only a minority of VIN lesions. PD-ECGF was found in the majority of lesions. CONCLUSION: Demonstration of angiogenesis may suggest which preinvasive lesions will progress to invasive cancer.
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