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  • Title: Influence of D-penicillamine on the immune response of mice.
    Author: Schumacher K, Maerker-Alzer G, Schaaf W.
    Journal: Arzneimittelforschung; 1975 Apr; 25(4):600-3. PubMed ID: 1098678.
    Abstract:
    Studies on the influence of D-ss, ss-dimethylcystein (D-penicillamine, Metalcaptase-R) on the primary immune response of mice after immunization with sheep red blood cells show, that D-penicillamine up to doses of 20 mg/kg has no effect on the synthesis of hemagglutinating antibodies. Plaque forming cells in the spleen were not significantly reduced after administration of 80 mg/kg. A striking inhibition of the formation of immune rosettes is demonstrated. 80 mg/kg led to a significant reduction of rosette forming B-lymphocytes in the spleen.
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