These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Suppression of mutations in mitochondrial DNA by tRNAs imported from the cytoplasm.
    Author: Kolesnikova OA, Entelis NS, Mireau H, Fox TD, Martin RP, Tarassov IA.
    Journal: Science; 2000 Sep 15; 289(5486):1931-3. PubMed ID: 10988073.
    Abstract:
    Mitochondrial import of a cytoplasmic transfer RNA (tRNA) in yeast requires the preprotein import machinery and cytosolic factors. We investigated whether the tRNA import pathway can be used to correct respiratory deficiencies due to mutations in the mitochondrial DNA and whether this system can be transferred into human cells. We show that cytoplasmic tRNAs with altered aminoacylation identity can be specifically targeted to the mitochondria and participate in mitochondrial translation. We also show that human mitochondria, which do not normally import tRNAs, are able to internalize yeast tRNA derivatives in vitro and that this import requires an essential yeast import factor.
    [Abstract] [Full Text] [Related] [New Search]