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  • Title: Can vitreous fluorophotometry predict the necessity for photocoagulation? A 5-year follow-up study.
    Author: Knudsen LL, Nielsen-Kudsk F.
    Journal: Acta Ophthalmol Scand; 2000 Aug; 78(4):390-5. PubMed ID: 10990038.
    Abstract:
    PURPOSE: To examine the long-term outcome of vitreous fluorophotometry including the predictability of retinopathic proliferative development in diabetic subjects. METHODS: 21 diabetic subjects were examined by long-term kinetic vitreous fluorophotometry and their barrier properties, as revealed by a permeability-index, were compared to a group of normal subjects. 13 diabetics were classified as having a high permeability-index, while 8 diabetics were classified as having a low permeability-index. The two groups were followed for 5 years with regard to development of proliferative retinopathy. RESULTS: 6 of 13 diabetics with a high permeability-index developed proliferative retinopathy within the 5-year follow-up period. This was in contrast to the low permeability-index group where none of 8 diabetics developed proliferative retinopathy. CONCLUSION: An increased permeability-index points towards an increased risk of development of proliferative retinopathy.
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