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  • Title: Lipid research. Possible new way to lower cholesterol.
    Author: Ferber D.
    Journal: Science; 2000 Sep 01; 289(5484):1446-7. PubMed ID: 10991725.
    Abstract:
    Clinicians may soon be able to mount a multipronged attack against cholesterol, the artery-clogging lipid whose buildup in the body is a major contributor to heart attacks and other cardiovascular diseases. In work reported on page 1524, a team has pinpointed a biological master switch in mice that controls three pathways that work together to both rid the body of excess cholesterol and prevent its absorption from the intestine. The work suggests a new mechanism for reducing cholesterol, for example, with drugs that turn up the activity of the master switch, a protein known as the retinoid X receptor.
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