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  • Title: Antimalarial phenanthrene amino alcohols. 3. Halogen-containing 9-phenanthrenemethanols.
    Author: Nodiff EA, Saggiomo AJ, Tanabe K, Chen EH, Shinbo M, Tyagi MP, Kozuka A, Otomasu H, Verma BL, Goff D.
    Journal: J Med Chem; 1975 Oct; 18(10):1011-9. PubMed ID: 1099200.
    Abstract:
    A series of new 9-phenanthrene amino alcohols has been prepared in which each compound bears from one to five halogen or halogen-containing moieties. A number of these compounds are extremely active against Plasmodium berghei in the mouse. Some structural requirements for optimal efficacy are considered.
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