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Title: Hürthle cell tumours of the thyroid. A review with emphasis on mitochondrial abnormalities with clinical relevance. Author: Máximo V, Sobrinho-Simões M. Journal: Virchows Arch; 2000 Aug; 437(2):107-15. PubMed ID: 10993269. Abstract: The molecular and enzymatic abnormalities of mitochondria in oxyphilic / oncocytic / Hürthle cells and their respective tumours are reviewed in a series of sections: "Mitochondria, ageing, neurodegenerative diseases and cancer", "Mitochondrial abnormalities in Hürthle cells and Hürthle cells tumours", "Mitochondrion-related alterations in tumours with and without Hürthle cell/oncocytic features", "True and secondary oxyphilia", and "Bcl-2 expression, apoptosis and necrosis in Hürthle cell tumours and tumour-like lesions". The clinicopathological and pathogenetic meaning of the data on record on these topics are discussed, with an emphasis on thyroid pathology.[Abstract] [Full Text] [Related] [New Search]