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  • Title: Antiphospholipid syndrome and perioperative hemostatic management of cardiac valvular surgery.
    Author: Hogan WJ, McBane RD, Santrach PJ, Plumhoff EA, Oliver WC, Schaff HV, Rodeheffer RJ, Edwards WD, Duffy J, Nichols WL.
    Journal: Mayo Clin Proc; 2000 Sep; 75(9):971-6. PubMed ID: 10994834.
    Abstract:
    Hemostatic aspects of antiphospholipid syndrome (APS) present unique challenges to clinicians and laboratory personnel alike, particularly in the perioperative period. These challenges are especially evident in patients requiring cardiac valve replacement surgery. However, the literature outlining the optimal approach in such patients is limited. We present the case of a 25-year-old woman with severe aortic regurgitation as a result of APS with particular reference to the precautions necessary during perioperative care. Particularly important are the prevention of thrombotic or hemorrhagic complications, management of associated thrombocytopenia, and laboratory methods of perioperative anticoagulation monitoring in the setting of prolonged clotting times.
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