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  • Title: L- and M-cone driven ERGs are differently altered in Best's macular dystrophy.
    Author: Scholl HP, Kremers J, Apfelstedt-Sylla E, Zrenner E.
    Journal: Vision Res; 2000; 40(22):3159-68. PubMed ID: 10996618.
    Abstract:
    To study the L- and M-cone pathways and their interactions in patients with Best's macular dystrophy (BMD), ERG response thresholds were measured to stimuli which modulated exclusively the L- or the M-cones, or both in various combinations. The ERG threshold data could be described with a vector addition model. Compared with normals, BMD patients showed generally larger amplitudes of the L-cone driven ERGs. However, the M-cone driven ERGs were similar in amplitude but significantly phase advanced. The data confirm our previous observations that L- and M-cone pathways can be affected differently by retinal degeneration, despite their large physiological and biochemical similarities.
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