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  • Title: Glycoprotein degradation: do sugars hold the key?
    Author: Frigerio L, Lord JM.
    Journal: Curr Biol; 2000 Sep 21; 10(18):R674-7. PubMed ID: 10996809.
    Abstract:
    Secretory glycoproteins that fail to fold or assemble correctly are retained in the endoplasmic reticulum and eventually degraded. Recent evidence shows that trimming of their N-linked oligosaccharide chains plays a key role in targeting glycoproteins for destruction.
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