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  • Title: [The effect of hypoxia of different origins and of the degree of its severity on the functional activity of the lysosomal apparatus].
    Author: Antonova II, Seredenko MM, Honchar OO, Koval' SB, Boiarchuk OD.
    Journal: Fiziol Zh (1994); 2000; 46(4):45-51. PubMed ID: 10997299.
    Abstract:
    We studied the activity of lysosomal enzymes (acid phosphatase and cathepsine D) and the status of lysosomal membranes of the liver, lung, heart and brain tissues of the male adult rats under acute hypoxia. We found that disturbances of lysosomal membranes permeability in these organs depend on the tissues hypoxia development, not yet on the genesis of hypoxic state. The lysosomal enzymes activation depends on the heaviness of the hypoxic influence.
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