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  • Title: Sickle cell disease in childhood: Part I. Laboratory diagnosis, pathophysiology and health maintenance.
    Author: Wethers DL.
    Journal: Am Fam Physician; 2000 Sep 01; 62(5):1013-20, 1027-8. PubMed ID: 10997528.
    Abstract:
    Over the past 25 years, morbidity and mortality have decreased significantly in children with sickle cell disease, and screening tests are now available to diagnose the disease in newborns. The incidence of sepsis caused by pneumococcal and Haemophilus influenzae infections has declined because of the prophylactic administration of penicillin soon after birth and the timely administration of pneumococcal and H. influenzae type b vaccines. Optimal nutrition can maximize growth in children with sickle cell disease, and timely screening can identify complications such as retinal damage and chronic renal involvement, thereby ensuring prompt treatment. Family physicians and parents who have been educated about sickle cell disease can detect acute, life-threatening complications such as splenic sequestration crisis and acute chest syndrome at their onset, thereby allowing treatment to be instituted without delay.
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