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  • Title: A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
    Author: Fukunaga K, Miyamoto E.
    Journal: Neurosci Res; 2000 Sep; 38(1):3-17. PubMed ID: 10997573.
    Abstract:
    Recent advances in molecular genetics provide strong evidence for a relationship between hippocampal long-term potentiation (LTP) and hippocampus-dependent memory. The alpha-CaM kinase II knock-out mouse and transgenic mice expressing a mutant form of CaM kinase II clearly demonstrate that CaM kinase II plays a prominent role in hippocampal LTP and hippocampus-dependent memory. Furthermore, the observation that there is a diversity of silent as well as functional synapses has shed light on the molecular basis of learning and memory during development as well as in adult brain. Here we present a working model of CaM kinase II activity as a memory molecule in hippocampal LTP and describe molecular targets of CaM kinase II involved in the establishment of functional synapses following LTP induction.
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