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  • Title: Neurohumoral effects of orphanin FQ/nociceptin: relevance to cardiovascular and renal function.
    Author: Kapusta DR.
    Journal: Peptides; 2000 Jul; 21(7):1081-99. PubMed ID: 10998543.
    Abstract:
    Orphanin FQ/Nociceptin (OFQ/N) is a peptide whose structure resembles that of the endogenous opioid peptides (endorphins). OFQ/N and its receptor are distributed in neural tissue and brain regions involved in the regulation of pituitary hormone release. Functional studies have shown that this peptide evokes a unique pattern of cardiovascular and renal excretory responses. This review will focus on the neural and humoral effects of OFQ/N and how this peptide may participate in the regulation of cardiovascular and renal function.
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