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  • Title: Convenient syntheses of 6-methylpurine and related nucleosides.
    Author: Hassan AE, Abou-Elkair RA, Montgomery JA, Secrist JA.
    Journal: Nucleosides Nucleotides Nucleic Acids; 2000 Jul; 19(7):1123-34. PubMed ID: 10999252.
    Abstract:
    Efficient methods for the synthesis of 6-methylpurine (3), 9-(2-deoxy-beta-D-erythro-pentofuranosyl)-6-methylpurine (8), and 6-methyl-9-beta-D-ribofuranosylpurine (5) are described. Methodology involving the (Ph3P)4Pd catalyzed cross-coupling reaction of CH3ZnBr with several different 6-chloropurine derivatives is described in high yield. This methodology now provides a facile and high-yielding synthesis of 8, which is needed in significant amounts for studies in cancer gene therapy.
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