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  • Title: Immunologic aspects of myasthenia gravis.
    Author: Lisak RP.
    Journal: Ann Clin Lab Sci; 1975; 5(4):288-93. PubMed ID: 1099979.
    Abstract:
    Clinical and pathologic features of myasthenia gravis suggest a possible autoimmune etiology. Myasthenia is found in association with other putative autoimmune diseases and autoantibodies including anti-muscle antibodies. There is also in vitro evidence for cell-mediated immunity to muscle in blood and thymic cells as well as a suggestion of antigenic disparity between blood and thymic cells. In addition, two experimental animal models are under investigation. It seems likely that the immune system plays a role in the pathogenesis, but what that role is and how it relates to neuromuscular block is not clear.
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