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  • Title: Inability of University of Wisconsin solution to reduce postoperative peritoneal adhesions in rats.
    Author: Cavallari N, Polistena A, Cavallaro A.
    Journal: Eur J Surg; 2000 Aug; 166(8):650-3. PubMed ID: 11003436.
    Abstract:
    OBJECTIVE: To examine the effect of University of Wisconsin solution (UWS) on the formation of postoperative peritoneal adhesions. DESIGN: Laboratory experiment. SETTING: University hospital, Italy. ANIMALS: 42 Sprague-Dawley rats. INTERVENTIONS: A standard lesion was made consisting of serosal trauma of the caecum and a parietal peritoneal defect. Rats were randomly divided into seven groups (n = 6 each): the first group acted as controls; the second had instilled normal saline 6 ml; the third Ringer's lactate 6 ml; the fourth UWS 6 ml; the fifth normal saline 12 ml; the sixth Ringer's lactate 12 ml; and the seventh UWS 12 ml. MAIN OUTCOME MEASURES: Adhesions were scored two weeks later for extent (0 to 4) and type (0 to 4). Adhesion strength was measured by a tensiometer. RESULTS: The mean (SEM) scores for extent and type of adhesions were significantly lower (p < 0.05) after instillation of Ringer's lactate 12 ml [1.0 (0.4) and 1.2 (0.4), respectively] than controls [3.5 (0.3) and 2.7 (0.2), respectively]. Adhesions were also significantly weaken (p < 0.05) [101 (33) g] than in controls [207 (6) g]. CONCLUSIONS: Intraperitoneal instillation of normal saline and UWS were ineffective in reducing the extent and type of adhesions. Although Ringer's lactate produced a significant reduction in severity, the effect was strongly volume related. This amount of fluid may be detrimental to a patient's postoperative course.
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