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  • Title: Temporal dependence of the inhibition by cytochalasin B of antigen-initiated migration inhibition factor production.
    Author: Sasson SZ, Rosenthal AS.
    Journal: J Immunol; 1975 Oct; 115(4):1140-2. PubMed ID: 1100722.
    Abstract:
    The effects of cytochalasin B on the antigen recognition process have been examined using an in vitro assay of macrophage-inhibition factor (MIF) production by activated guinea pig T lymphocyte-enriched populations. The data indicate that cytochalasin B inhibits MIF production if added at the initiation of culture but not if added 2 hr after antigen. These data are interpreted as consistent with either an inhibition by cytochalasin B of the physical assoication of antigen-bearing marcrophage and lymphocytes or with an inhibition of the access of antigen to the T lymphocyte receptor.
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