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  • Title: Endocapillary proliferative glomerulonephritis in a patient with parvovirus B19 infection.
    Author: Komatsuda A, Ohtani H, Nimura T, Yamaguchi A, Wakui H, Imai H, Miura AB.
    Journal: Am J Kidney Dis; 2000 Oct; 36(4):851-4. PubMed ID: 11007690.
    Abstract:
    A 45-year-old woman developed acute nephritic syndrome after erythema infectiosum. Laboratory data on admission showed decreased serum C3, C4, and CH50 levels and the presence of both immunoglobulin (Ig) M and IgG antibodies to human parvovirus B19 (HPV). A renal biopsy showed diffuse endocapillary proliferative glomerulonephritis. Immunofluorescence microscopy indicated 2+ granular staining for IgG, IgM, and C3 over the mesangial area and along glomerular capillary walls. HPV antigen was also detected in glomeruli by immunohistochemistry. Electron microscopy showed electron-dense deposits in the subendothelial space and the paramesangial area. These findings suggest that immune complex-type glomerulonephritis is caused by glomerular deposition of HPV antigen-antibody complexes in some patients with HPV infection.
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