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  • Title: Antimalarials. 7.2,8-Bis(trifluoromethyl)-4-quinolinemethanols.
    Author: Blumbergs P, Ao MS, LaMontagne MP, Markovac A.
    Journal: J Med Chem; 1975 Nov; 18(11):1122-6. PubMed ID: 1100828.
    Abstract:
    Based on the high antilalarial activity of alpha-(2-piperidyl)-2,8-bis(trifluoromethyl)-4-quinolinemethanol, ten additional 2,8-bis(trifluoromethyl)-4-quinolinemethanols were prepared in which the amino alcohol side chain was structurally varied. Synthesis of the compounds is described and antimalarial activity data against Plasmodium berghei are presented and discussed in terms of the structure variations.
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