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  • Title: High-density lipoprotein cholesterol and triglyceride response with simvastatin versus atorvastatin in familial hypercholesterolemia.
    Author: Wierzbicki AS, Lumb PJ, Chik G, Crook MA.
    Journal: Am J Cardiol; 2000 Sep 01; 86(5):547-9, A9. PubMed ID: 11009276.
    Abstract:
    The clinical and biochemical determinants of high-density lipoprotein (HDL) and triglyceride response to simvastatin and atorvastatin were assessed in 150 patients with severe hyperlipidemia treated in a randomized open-trial format design. Triglyceride reduction was only dependent on HDL:apolipoprotein A1, change in apolipoprotein B, and dose response, whereas an increase in HDL was dependent on initial LDL, change in LDL or dose response, and therapy with simvastatin.
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