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  • Title: Synthesis and antiproliferative evaluation of 7-aminosubstituted pyrroloiminoquinone derivatives.
    Author: Bénéteau V, Pierré A, Pfeiffer B, Renard P, Besson T.
    Journal: Bioorg Med Chem Lett; 2000 Oct 02; 10(19):2231-4. PubMed ID: 11012036.
    Abstract:
    Coupling of five amines on the 7-methoxy-1,3,4,5-tetrahydropyrrolo[4,3,2-de]quinoline core was achieved and afforded, in particular, an opened analogue of the natural alkaloid wakayin. Evaluation of cytotoxic activity of compounds 2, 10-13 on L1210 cells afforded IC50 in the range 0.25 5.3 microM.
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