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  • Title: The fractional urinary fluoride excretion in young children under stable fluoride intake conditions.
    Author: Villa A, Anabalón M, Cabezas L.
    Journal: Community Dent Oral Epidemiol; 2000 Oct; 28(5):344-55. PubMed ID: 11014511.
    Abstract:
    The purpose of this study was to determine the fraction of the total daily fluoride intake that is excreted through the urine (FUEF) of children aged 3-5 years under usual intake conditions. Participating children were residents of an area with a fluoride (F) concentration of 0.5-0.6 mg/L in their drinking water. Assessments were made on two successive 24-h periods on 20 children, measuring the total amount of fluoride ingested through liquid and food consumption, and from ingestion of fluoridated toothpaste (500 microg F/g), together with the determination of the amount of fluoride excreted through urine. Fluoride retention was also estimated assuming a constant average F fraction of 10% excreted through faeces. It was found that the average proportion of liquids, solid foods, and toothpaste to the daily fluoride intake (1.02-mg F/day on average) were 40.8, 34.6, and 24.5%, respectively. The average FUEF value was 35.5% (95% C.I.=31.7-39.3%), and the estimated fractional F retention was 54.5%. The present data suggest a slight relationship between FUEF values and the inverse of the daily fluoride dose (1/dose) (r=0.513; P=0.021). When the present results are combined with those from previous studies on F-retention and urinary excretion, the correlation between both FUEF and fractional retention and 1/dose are very strong and highly significant (r=0.98, P<0.0001, and r=-0.986, P<0.0001, respectively). A possible mechanism is suggested in order to explain this latter finding. The potential usefulness of the current FUEF value for the estimation of daily F intake (or dose) from urinary F excretion data is also discussed.
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