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  • Title: [Characteristics of the pathomorphological manifestation of salmonella infection in guinea pigs and hamsters].
    Author: Lobanova ZI, Orlovskiĭ VI, Bochkov IA.
    Journal: Arkh Patol; 1975; 37(8):20-5. PubMed ID: 1101854.
    Abstract:
    Observations on the manifestations of salmonellosis infection in various species of laboratory animals made it possible to establish general regularities inherent to this infectious disease, to reveal features depending on metabolic, morphological and microbiological characteristics of a given species of animals. These comparative data are of importance for understanding the factors determining resistance or sensitivity of the macroorganism to infection. Pathomorphological and microbiological investigations of experimental salmonellosis infection in hamsters and guinea-pigs showed that changes characteristic of this infection were manifested considerably weaker in guinea pigs than in hamsters. Of special interest were lesions of the large intestine mucosa wall in guinea pigs and those of the lungs in hamsters. These data may be a subject of a special study. Development and course of the experimental infection were not accompanied by the development of disbacteriosis. Pathogenic bacteria were eliminated on the 2nd--4th day in guinea pigs and on the 5--7th day in hamsters.
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