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  • Title: [Fludarabine treatment of chronic lymphoid leukemia].
    Author: Gabeeva NG, Pivnik AV, Moiseeva TN, Zybunova EE, Samoĭlova RS, Kremenetskaia AM, Varlamova EIu, Kaplanskaia IB.
    Journal: Ter Arkh; 2000; 72(8):42-5. PubMed ID: 11019427.
    Abstract:
    AIM: To try effectiveness of fludarabine monotherapy in verified chronic lymphoid leukemia (CLL) in pretreated patients. MATERIAL AND METHODS: The treatment effectiveness according to the international criteria of complete and partial remission was assessed in 37 patients with progressive, splenic, tumor and bone marrow forms of CLL given 5-day courses of fludarabine in a single daily dose 25 mg. RESULTS: In progressive CLL, the remission was achieved in 45% of the patients (10% complete and 35% partial), in splenic form--62.5% (12.5% complete, 50% partial), in tumor form--50% (100% partial). In bone marrow form no remissions were obtained. CONCLUSION: Fludarabine is effective in therapy of pretreated CLL patients. The treatment should be adjusted to CLL form.
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