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  • Title: Monoclonal immunoglobulin G cryoglobulinemia and multiple myeloma in a domestic shorthair cat.
    Author: Hickford FH, Stokol T, vanGessel YA, Randolph JF, Schermerhorn T.
    Journal: J Am Vet Med Assoc; 2000 Oct 01; 217(7):1029-33, 1007-8. PubMed ID: 11019710.
    Abstract:
    A 13-year-old castrated domestic shorthair cat was examined because of fever, anorexia, and dermatologic lesions. Crusting, erythema, and well-demarcated purple discoloration of the foot pads and the tips of the pinnae, nose, and tail were seen. A white flocculent precipitate was detected in cooled serum. This precipitate dissolved upon rewarming, consistent with a cryoglobulin. Hypercalcemia, high alanine and aspartate aminotransferase activities, thrombocytopenia, and a monoclonal IgG gammopathy were found. Numerous hepatic nodules were detected by means of abdominal ultrasonography. Cytologic evaluation of fine-needle aspirates of the liver and spleen revealed numerous plasma cells, and evaluation of a bone marrow aspirate revealed plasmacytosis. A diagnosis of multiple myeloma and monoclonal IgG cryoglobulinemia was made, and the cat was euthanatized.
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