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  • Title: Liver resistance to toxic effects of CCl(4) under conditions of gadolinium chloride depression of Kupffer cells.
    Author: Cyrendorzhiev DD, Kutina SN, Zubakhin AA.
    Journal: Bull Exp Biol Med; 2000 Jun; 129(6):605-7. PubMed ID: 11022262.
    Abstract:
    Acute toxic hepatitis was modeled in (CBAxC57B1)F1 mice by single injection of 40% CCl(4) in oil. Pretreatment with gadolinium chloride, a selective blocker of Kupffer cells, considerably potentiated damage to hepatocytes leading to generalization of this process, delayed inflammatory infiltration, and inhibited reparative processes. Zymosan administered against the background of gadolinium chloride blockade improved liver resistance to CCl(4)-induced damage, intensified mononuclear infiltration, and accelerated reparative processes.
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